ABSTRACT
Head pain can be generated by a multitude of structures, but the brain parenchyma itself is not one of them. The brain has either no or minimal sensory innervation with pain fibers. However, the coverings of the brain (meninges), meningeal blood vessels, and large cerebral arteries and veins all are highly innervated, and thus when stimulated, could cause head pain (Fig. 1). In addition, neck structures and paranasal sinuses can contribute to head pain. This chapter will look at the potential pain sensitive intracranial and extracranial structures.
