ABSTRACT

Neuronal and glioneuronal tumors of the central nervous system (CNS) constitute a diverse group of lesions that includes hamartoma-like tumors as well as highly cellular and locally aggressive neoplasms. Poorly differentiated neuroblastic tumors are considered distinct from this group, and within the embryonal tumor category. Some suggest that glioneuronal hamartomas and neoplasms have common precursors that undergo abnormal divergence and differentiation (1). This suggestion is further supported by an increasing number of reported tumors with coexisting patterns, blurring the boundary between hamartoma and neoplasm.