ABSTRACT
Linkage analysis methods have facilitated successful mapping and identifi-
cation of genes for many Mendelian diseases, but the utilization of linkage methods for mapping quantitative traits, such as lung function mea-
surements, and complex diseases, such as chronic obstructive pulmonary
disease (COPD), has proved more challenging. This chapter will provide
a brief introduction to linkage analysis, followed by a discussion of linkage
analysis of pulmonary function measures in the general population and in
COPD families.
