ABSTRACT
Positron emission tomography (PET) is a fundamental component in the field of molecular imaging. The inherent quantitative nature of PET combined with the high sensitivity of the instrumentation makes this imaging modality ideal for many clinical applications. The copper PET nuclides have been extensively studied because of their range of decay schemes allowing for versatile and selective use of the copper nuclide depending on the application. Gallium-66 can be used as a substitute for the photon emitter 67Ga commonly used in single photon emission computed tomography (SPECT) imaging. The radionuclide 89Zr is an attractive target for further research for use in PET imaging because of its long half-life of 78.4 hours, which makes it ideal for the radiolabeling of slowly localizing antibodies. It has also been suggested as a surrogate for monitoring Y- and In-antibody distribution.
