ABSTRACT
The molecular pathogenic mechanisms for obesity and related disorders are still largely unknown. The identification of physiological and biological factors underlying the metabolic disturbances observed in obesity is a key step in developing better therapeutic outcomes. Obesity is a complex phenomenon characterized by an increased fat mass in different anatomical sites. In addition, each stage in the development of obesity, weight gain, weight maintenance, and variable response to treatment, could probably be associated with different molecular mechanisms. Adipose tissue present, we do not know for example of any biological markers or molecular predictors of passing from one stage to the other (1). For a better understanding of the development of obesity, in vitro and in vivo studies of adipocyte differentiation, differences between each type of fat depot and the development of related disorders are essential to identify the key gene involved in these phenomena.
