ABSTRACT
In the manufacture of tablets it is often necessary to include a wet granulation step. Wet
granulation serves several purposes, including increasing particle size, supplying a binder
to the formulation, improving flow and compression characteristics, and improving
content uniformity (2-10). In the context of drying wet granulations, drying is usually
understood to mean the removal of water (or other liquid) from a solid or semi-solid mass
by evaporative processes. Some drying processes may be abetted by mechanical removal
of liquid prior to the drying step. Mechanical removal of the liquid is generally not
feasible for wet granulation but could offer economic advantages as a pre-drying step for
other pharmaceutical drying processes that are not concerned with maintaining a par-
ticular particle size.
