ABSTRACT
The clinical manifestations of gout ultimately reflect consequences of urate/uric
acid crystal deposition from biological fluids supersaturated for urate, the
sparingly soluble end-product of purine metabolism in humans. Study of the
biochemistry of gout, therefore, focuses on the processes determining urate levels
in health and on alterations in these processes that result in states of urate
supersaturation. Several definitions should expedite the aims of this discussion.