ABSTRACT
Experimental study of intracerebral hemorrhage (ICH) in animal models has increased dramatically in the last several years. A PubMed search on January 1, 2005, for articles with the keywords “intracerebral hemorrhage” or “hematoma” and “animals” generated almost 300 references written since 1968. Two-thirds of these reports appeared in the last 5 years. These citations by researchers worldwide demonstrate a wide range of investigations examining all aspects of the disorder. The importance of experimental animal models for ICH research is that they permit a detailed examination of the pathophysiologic, biochemical, and molecular processes, as well as the mechanisms underlying brain tissue injury. They also enable testing of new pharmacologic and surgical therapies.
