ABSTRACT
Nontraumatic intracerebral hemorrhage (ICH) accounts for approximately 10% to 15% of all cases of stroke and is associated with high rates of morbidity and mortality ( 1-5 ). To date, no proven specifi c or effective treatment for ICH exists, nor do clear guidelines regarding management of blood pressure and appropriate timing and indications for performing surgery ( 6 ). One of the limitations in developing interventional protocols is the fact that we lack knowledge regarding the temporal response of the human brain to ICH because we have no good test to measure it and much of what we know is based on the animal model. A better understanding of the pathophysiology of the perilesion injury is required in order to develop new therapeutic strategies.
