ABSTRACT
The establishment of chromosomal sex (46,XY or 46,XX) is considered the first step in normal sexual differentiation. However, the first sexual structures that form may be considered as either primordial or neutral. The term sex determination refers to the process in which the primordial gonad is committed to development as testis or ovary. Sex differentiation refers to the development of the internal accessory duct structures and external genitalia (1-5).
