ABSTRACT
Quantitative estimation of internal dose is a key step in the risk assessment of nanoparticles. Lung dosimetry models describe the deposition and clearance of inhaled particles in the respiratory tract, but these models have not been fully validated for the disposition of nanoparticles, which may include translocation beyond the respiratory tract. The current models and methods will be discussed, along with the data needs and challenges to validate and extend these models to better estimate nanoparticle dose.
