ABSTRACT
CHALLENGES AND PROSPECTS FOR VACCINEINDUCED PROTECTION AGAINST HIV Human immunodeficiency virus type 1 (HIV-1) has caused a devastating and persistent global epidemic with profound consequences on human health and socioeconomic stability. The greatest burden of disease occurs in resource-poor settings where education, diagnosis, care, and treatment are not readily available. Each day approximately 7,000 persons are infected by HIV-1, including approximately 1,000 persons per day under the age of 15 years. The development of a vaccinewould have amajor impact on the spread of this disease, either by preventing infection and/or reducing viremia to slow the rate of disease progression and transmission. It remains an urgent public health need.
