ABSTRACT
Reports between 1920 and the early 1960s focused on the clinical and biologic manifestations of HSV as well as the natural history of human disease. During these four decades, the host range of HSV infections was expanded to include a variety of laboratory animals, chick embryos, and, ultimately, in vitro cell culture systems. Expanded animal studies demonstrated that transmission of human virus to the rabbit resulted not only in corneal disease, but also could lead to infections of either the skin or central nervous system (11), as reviewed (3,12-14).
