ABSTRACT

Although it is well accepted that obesity is a health hazard and a risk factor for cardiovascular disease (CVD) and type 2 diabetes (1-4), physicians have been perplexed by the remarkable heterogeneity noticed among equally obese individuals. For instance, some obese patients are not characterized by any CVD risk factors, whereas others have type 2 diabetes and/or clinical signs of coronary heart disease (CHD) (5-10). Thus, although we recognize that obesity causes prejudice to health, why is this condition so heterogeneous in terms of its clinical manifestations?