ABSTRACT
Most local and systemic reactions, which develop during subcutaneous allergen immunotherapy (SCIT), occur within 20 to 30 minutes of injection but can occur later than 30 minutes. Subcutaneous nodules at the site of injection are more common with aluminum-adsorbed vaccines, may persist but usually disappear, and do not necessitate an adjustment in the immunotherapy (IT) dose. Patients who develop nodules that persist should be injected with aqueous preparations.
