ABSTRACT
Platelets play an important role in thrombus formation. They adhere to exposed subendothelial structures in response to vascular injury and become rapidly activated by interaction with thrombogenic substrates and agonists released or generated locally, such as adenosine-5’-diphosphate (ADP), thromboxane A2, and thrombin. In this manner, they acquire the ability to bind soluble adhesive molecules that become the reactive surface for continuing platelet deposition (platelet aggregation).
