ABSTRACT
INTRODUCTION Solid-state NMR (SSNMR) spectroscopy has been used to study polymorphism beginning with the analysis of hydroquinone by Ripmeester almost 30 years ago (1). The characterization of pharmaceutical polymorphs by SSNMR spectroscopy has become more common in the last 10 to 15 years as the technology has improved and NMR spectrometers have become easier to use, particularly for non-specialists. SSNMR spectroscopy provides unique information due to its selectivity and specifi city compared to other analytical techniques, which makes it very valuable for characterization of pure compounds and well as mixtures.
