ABSTRACT
INTRODUCTION Studies of the propensity of one polymorphic form of a substance to transform into a different polymorphic form are equally important to the pharmaceutical scientist as are studies designed to obtain the different forms and deduce methods for their preparation. It is not suffi cient to be able to prepare a particular polymorphic state and develop conditions for its manufacture on a desirable scale because if that particular solid-state form is highly metastable then its maintenance in that form could prove to be problematic. Hence, determining the possible phase transformation pathways associated with the various polymorphs of a given substance is equally important to establishing the phase space of the crystal forms available to that substance.
