ABSTRACT
INTRODUCTION For those suffering with allergy to aeroallergens, it is self-evidently clear that the inhalation of allergen (pollen, cat dander, etc.) directly leads to symptoms that are best explained by nerve activation (itchy sensations, sneezing, coughing increased secretions, etc.). The simplest explanation for this is the allergen activation of tissue mast cells resulting in the release of neuroactive mediators. It is also evident that a subset of allergic subjects becomes hypersensitive to irritants other than the allergens that may include particulate matter, excessive temperature, anosmotic solutions, acid, smoke, volatile gases, perfumes, pollutants, etc.
