ABSTRACT
This chapter collects and synthesizes up-to-date information about the complex etiologic theories and treatment regimens associated with fibromyalgia (FM) and its association with depressive syndromes. There are many overlapping pain and depression comorbidities, and we have specifically chosen to review depression and FM for a few reasons. First, FM has been a controversial illness with several proposed etiologies. Second, FM may be more of a neuropathic pain condition with organic and functional etiologic overlap with depression pathology. Third, in the last year we have gathered three new FDA approvals for treating this pain disorder. Fourth, many of the neuropathic and nociceptive treatment options that we discuss can easily be applied to other pain conditions associated with depression.
