ABSTRACT

INTRODUCTION With the advent of more and more sophisticated pharmaceutical products of varying stabilities, toxicities, solubilities, and bioavailabilities, there has arisen the requirement for the development of generic drug delivery systems that will enable delivery of these molecules via various routes, with controlled release rates and the potential to be targeted to different sites within the body. Additionally, these delivery systems should be able to entrap molecules ranging in size from several hundred daltons to >200 kDa, and yet be small enough to travel throughout the body. These needs are met largely by the nanoparticle delivery systems described below.