ABSTRACT

INTRODUCTION The success of any therapeutic agent depends not only upon its pharmacokinetic/ pharmacodynamic properties and bioactivity, but also on its bioavailability at the site of action in the human system (1-3). This is especially true for protein drugs used as therapeutic agents. Although several protein drug delivery strategies have been explored, none has proved fully satisfactory because of the limitations posed by the sensitivity of protein structures to environmental conditions (4-6).