ABSTRACT
The use of cell culture techniques in toxicological investigations is referred to as in vitro cytotoxicology, or in vitro toxicology. The latter term also includes noncellular test systems, such as isolated organelles or high-throughput (HTP) microarrays. The reasons for the increasing interest and success of these techniques in clinical and research toxicology testing are a consequence of the considerable advancements realized since the advent of the technology:
1. Since the growth of the first mammalian cells were described in capillary glass tubes, cell culture technology has been extensively refined.
