ABSTRACT

TRENDS IN THE DEVELOPMENT OF HPLC CHIRAL STATIONARY PHASES In any account of drug stereochemistry, the development of commercially available chiral stationary phases (CSP) warrants some attention. This area of scientific endeavor has made a significant impact on the study of drug stereochemistry and indeed on the entire pharmaceutical industry. It has also been a major success story over the past quarter century, reaching maturity very quickly but also seeing nonstop activity and useful developments in the ensuing period. Not surprisingly then, it has been extensively chronicled already (1-6). However, such has been the volume of activity that it is still necessary to pick out the important trends from the wealth of detail available.