ABSTRACT
I. Introduction Advanced pulmonary disease (APD) refers to a group of chronic, non-neoplastic lung disorders characterized by progressive decline in lung function, impaired quality of life (QOL), and premature mortality (1). Medical comorbidities in this population are common and may adversely affect prognosis before and after lung transplantation (LT). When severe, nonpulmonary disorders may be considered relative contraindications to transplant candidacy (2). We will review selected medical comorbidities including coronary artery disease (CAD), malnutrition, osteoporosis, and deconditioning, with particular attention to the available evidence for pretransplant optimization.
