ABSTRACT
Adipose tissue is vascular, leading to the theory that cellulite may worsen in predisposed areas where circulation and lymphatic drainage have been decreased, possibly due to local injury or in ammation. In response to impairment of microvascular circulation, there is increased microedema within the subcutaneous fat layer, causing further stress on surrounding connective tissue bers and accentuation of skin irregularities [2,4]. Many of the currently accepted cellulite therapies target de ciencies in lymphatic drainage and microvascular circulation. e lipids within adipocytes are derived from plasma-circulating lipoproteins. In a dynamic process, the stored fat is hydrolyzed and eliminated again to the plasma as free fatty acids and glycerol. Various enzymes, including insulin and cyclic AMP participate in this process. In particular, triglyceride lipase is very important in the promotion of lipolysis. is enzyme is activated by adenylyl cyclase stimulation by means of an antagonist e ect. is inhibitory process causes triacylglycerol hydrolysis and releases free fatty acids and glycerol into the interstitial space and plasma.
