ABSTRACT
Electroporation is the transitory structural perturbation of lipid bilayer membranes due to the application of high voltage (HV) pulses (100V). HV pulses are applied for a very short duration to enhance macromolecular transport reversibly by permeabilizing the SC [25]. e skin resistance drops by several orders of magnitude during HV pulsing and is partly reversible [22]. In vitro transportation is increased up to four orders of magnitude compared to passive di usion and the electrical fractional area for small ion transport is approximately 0.1% [22]. Unlike mechanical skin puncture, electroporation itself is self-localizing to the SC, because initial high SC resistance causes most of the transdermal voltages to be concentrated across the SC [21].
