ABSTRACT
INTRODUCTION Chlorine dioxide (CD) is a highly effective sterilizing agent that has many applications in the pharmaceutical industry including the decontamination of isolators and their contents and the decontamination of clean rooms. It has two primary features that make it extremely effective and well suited for use in isolators, clean rooms, and sterilization. It is a true gas at normal use temperatures and therefore is not susceptible to condensation issues and temperature gradients. It has a yellowish-green color, which allows its concentration to be precisely monitored and controlled by a UV-vis spectrophotometer. This gives the ability to provide tight process control from beginning to end.
