DEFINITION OF MYOCARDIAL INFARCTION Myocardial infarction (MI) is defined pathologically as myocardial cell death due to prolonged ischemia. In the clinical setting these conditions are met when the following criteria are present: Detection of a rise and/or fall of cardiac biomarkers with at least one value above the 99th percentile of the upper reference limit (URL) together with evidence of myocardial ischemia as recognized by at least one of the following: symptoms of ischemia, ECG changes of new ischemia or development of pathological Q waves, or imaging evidence of new loss of viable myocardium or new regional wall motion abnormality (Table 1) (1).