ABSTRACT
Surgical developments over the last 10 years in resection of liver metastases have resulted in improved long-term survival. Several large surgical series have shown 5-year survival rates averaging 30% to 40%, and in some patients a chance of cure, with 20% survival at 10 years after hepatic resection ( 8-10 ). Developments in chemotherapy, both systemic and regional, have resulted in a radically changed landscape for patients with metastatic CRC. Those patients who present with initially unresectable liver metastases, 80% to 85% of cases, may now have the chance of hepatic resection after chemotherapy downstaging. Even if liver resection is not possible, median survival has increased with modern chemotherapies ( 3 , 11 ).
