ABSTRACT
Primary Infection Fetal infection generally (99.5%) occurs following maternal primary infection, and rarely following recurrent CMV infection (Fig. 46.1). Of the women who are not immune (IgG, IgM) for CMV at the beginning of pregnancy, about 2% acquire maternal infection. Transplacental transmission may occur weeks or months after primary maternal CMV infection, and can be isolated from the AF by a PCR DNA technique to positively identify intrauterine transmission of CMV. Overall, about 15% to 20% of infected infants develop sequelae (so about 5-8% of infants of infected mothers have sequelae).
