ABSTRACT
ETIOLOGY/BASIC PATHOPHYSIOLOGY Paroxysmal discharges of neurons occur when the threshold for firing of neuronal membranes is reduced. The pathophysiology of epileptic disorders is not very well understood. Structural abnormalities of neuronal transmitter receptors, channelopathies, excessive excitatory activity, cortical remodeling, and loss of inhibitory neuronal activity have all been implicated as possible mechanisms.
