ABSTRACT
Many disorders result in disturbances of pigment formation by the melanocytes (1). Hypomelanosis or a decrease in the formation of the pigment melanin may be caused by many disorders. Leukoderma, derived from the Greek terms, λευκο white + δερµα skin, due to chemical exposure has been associated with several classes of compounds; most being phenols or thiols. These chemicals are useful as antioxidants and fi nd utility in rubbers and plastics, in foods, and as polymerization inhibitors in monomers. Because of the widespread use of these chemicals, it is important to examine the effects of exposure and the mechanism of depigmentation.
