ABSTRACT
The last decade has seen a marked expansion in interest in metal allergic contact dermatitis (ACD)—from a focus mainly on nickel and chromate to currently gold, cobalt, palladium, and others. Orthopedic implants provide the impetus for much of this interest. Case report methodology now is much of the literature citations in this area. Here we critically review the citations and suggest diagnostic criteria that might clarify how hypersensitivity to copper often occurs in man.
