ABSTRACT
Osteoporosis is defined as a reduction in bone mass and disruption of bone architecture, resulting in reduced bone strength and increased fracture risk. Fragility fractures are the hallmark of osteoporosis, and they are particularly common in the spine, hip and forearm. These fractures show a steep age-related increase and have a major impact on the health of elderly populations in the western world, causing significant morbidity and mortality. They impose huge financial burdens on health services throughout the world. Demographic changes and increasing life expectancy will lead to a dramatic increase in the number of people suffering from fractures over the next few decades (Figure 19.1) unless more effective action is taken to prevent the disorder.
