ABSTRACT
The aminoquinoline antimalarials, which include quinine, quinacrine, chloroquine and mefloquine have been the most widely used antimalarials from the beginning of this century until the present. Quinine was isolated from the bark of the Cinchona tree by Caventou and Pelleitier in 1820, and the correct structure was proposed by Rabe (1908). Effective clinically, its use declined between the 1940s and the 1960s owing to the introduction of new, effective synthetic antimalarial drugs such as the 4-aminoquinoline, chloroquine.
