ABSTRACT
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The study of carbonic anhydrase inhibitors (CAIs) followed and completed the biochemical and physiological investigations on the enzyme after its discovery. Besides sulfonamides, which act as powerful CAIs, inorganic anions inhibit the metalloprotein with sufficient potency to generate significant physiological consequences. Their diverse inhibition properties against different carbonic anhydrase isozymes are discussed, from both the kinetical and structural points of view. Other classes of nonsulfonamide CAIs, some of them recently discovered, are also reviewed.
