ABSTRACT

The enzyme carbonic anhydrase (CA, carbonate hydrolase, EC 4.2.1.1) is involved in a variety of physiological and physiopathological processes. [For a review see Maren (1967) and for updates see Maren (1984, 1987, 1991) and Maren et al. (1993, 1994).) Among its inhibitors, sulfonamides are important clinical agents, used to treat glaucoma(Supuran 1993; Maren 1984, 1987, 1991; Maren et al. 1993), gastroduodenal ulcers (Puscas 1984), certain neurological disorders (Lindskog and

Wistrand 1987).