In this chapter, the authors present seven integrative, transdiagnostic principles for effective group therapy with adolescents. These principles include: utilizing brief exposure, maximizing the interpersonal rewards, developing the group as a complex system, playing with paradox and perception, working the edge, facilitating movement between experience and reflection, and engaging with the future. Each is presented with a theoretical rationale, supporting research, and clinical illustrations. The authors also advocate for the importance of group leaders supporting adolescent development and present considerations for how leaders might position themselves with adolescent group members. Group planning, pre-group preparation, and the use of a tri-partite structure for sessions are all outlined.