The author discusses how group leaders may make use of research on group therapy with adolescents, particularly group process research, to engage in evidence-based practice. The limitations of evidence-supported treatments are discussed as they relate to adolescents, and recent findings about practice-based evidence are presented. The author synthesizes the growing evidence base for creative arts-based groups, including consideration of therapeutic factors that are specific to these approaches. The qualities of effective adolescent therapists are presented, as are findings about group therapy related to cohesion, group climate, and group composition (including factors such as attachment style, gender, age range, and group size). The importance of active engagement of adolescent group members is emphasized, as this quality relates to outcomes.