The restitution of human remains has had a particular development in Argentina since the return of democracy in 1983 within the framework of the recognition of the rights of Indigenous peoples. Various circumstances contributed to the formation of important collections of Indigenous human remains since the nineteenth century, especially those kept at the Museo de La Plata. In the last four decades, these remains have generated growing complaints, claims, and disputes. Legal changes and new codes of professional ethics for archeologists and bioanthropologists have been key milestones to notice the change of era. In this chapter, this issue is analysed, focusing on legal changes and the main cases of restitution, to further discuss the current debate that involve museums, researchers, Indigenous peoples, and relevant authorities.