ABSTRACT

Neurological impairment is now recognized as a serious and common complication of HIV brain infection in the setting of frank AIDS (Navia, Jordan, & Price, 1986). By the final phase of illness, approximately two thirds of all people with AIDS (PW As) manifest a pattern of diffuse impairment, known as the AIDS dementia complex (ADC). An additional quarter manifest more limited symptoms (Price et al., 1988). Furthermore, at autopsy, neuropathological evidence of CNS disease has been detected in 78% of the brains studied (Nielsen, Petito, Urmacher and Posner, 1984).