ABSTRACT
Serotonin and Affective Disorders ................................................................. 240 Chemical Emotion ....................................................................................... 240 5HTTLPR, Life Events and Clinical Depression........................................ 242
Trophic Theory of Depression ......................................................................... 244 Cortisol and Depression .................................................................................. 246
Corticosteroids: An Essential but Temporally Complex Neuroendocrine Signal ........................................................................... 246
Early Life Experience Regulates Corticosteroids During Adulthood ...... 247 Corticosteroid Acquired Neuroendangerment .......................................... 249 Cortisol, Serotonin and BDNF .................................................................... 250
Conclusions ...................................................................................................... 251 Note .................................................................................................................. 251 References ........................................................................................................ 251
The characteristics and severity of a depressive episode may depend on the extent of the involvement of both atypical early neurogenesis and acquired neuroendangerment in etiology. Future research studies must use genetically and physiologically sensitive designs to examine the nature of emotion regulation and cognitive processing in the onset, outcome, and treatment response of depressive disorders in young people.
