ABSTRACT
Specimens from 45 human brains were obtained during au topsies conducted at the Allegheny County Coroner’s Of fice, Pittsburgh, Pa (Table 1). Informed consent for brain donation was obtained from the next of kin. Neuropathological abnormalities were detected in 6 subjects. Subject 517 had a vascular malformation and hemorrhage con fined to the right temporal lobe, and subject 622 had an acute infarction limited to the distribution of the right middle cerebral artery. However, the cortical regions of interest for the present study were not affected in either subject. In 4 subjects (subjects 532, 564, 609, and 632), thioflavine S staining revealed a few senile plaques without any neuro fibrillary tangles. The density of plaques was insufficient to meet the diagnostic criteria for Alzheimer disease,37 and there was no history of dementia in any subject.
