Acknowledgments Bromet, E.J., and Fennig, S. “Epidemiology and Natural History of Schizophrenia.” Biol Psychiatry 46 (1999): 871-881. Reprinted with the permission of Elsevier Science. Heaton, R.K., Gladsjo, J. A., Palmer, B.W., Kuck, J., Marcotte, T.D., and Jeste, D.V. “Stability and Course of Neuropsychological Deficits in Schizophrenia.” Arch Gen Psychiatry 58 (2001): 24-32. Reprinted with the permission of American Medical Association. Robinson, D., Woerner, M.G., Alvir, J.M., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., and Lieberman, J. A. “Predictors of Relapse following Response from a First Episode of Schizophrenia or Schizoaffective Disorder.” Arch Gen Psychiatry 56 (1999): 241-247. Reprinted with the permission of American Medical Association. Akil, M., Pierri, J.N., Whitehead, R.E., Edgar, C.L., Mohila, C., Sampson, A.R., and Lewis, D. A. “Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects.” AmJ Psychiatry 156 (1999): 1580-1589. Copyright 1999, the American Psychiatric Association. Reprinted by permission. Arnold, S.E., Trojanowski, J.Q., Gur, R.E., Blackwell, P., Han, L.Y., and Choi, C. “Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients with Schizophrenia.” Arch Gen Psychiatry 55 (1998): 225-232. Reprinted with the permission of American Medical Association. Barch, D.M., Carter, C.S., Braver, T.S., et al. “Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients with Schizophrenia.*'Arch Gen Psychiatry 58 (2001): 280-288. Reprinted with the permission of American Medical Association. Gilbert, A.R., Rosenberg, D.R., Harenski, K., Spencer, S., Sweeney, J.A., and Keshavan, M.S. “Thalamic Volumes in Patients with First-Episode Schizophrenia.” AmJ Psychiatry 158 (2001): 618-624. Copyright 2001, the American Psychiatric Association. Reprinted by permission. Glantz, L.A., and Lewis, D.A. “Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia.” Arch Gen Psychiatry 57 (2000): 65-73. Reprinted with the permission of American Medical Association. Goff, D.C., and Coyle, J.T. “The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia.” AmJ Psychiatry 158 (2001): 1367-1377. Copyright 2001, the American Psychiatric Association. Reprinted by permission. Goldstein, J.M., Goodman, J.M., Seidman, L.J., et al. “Cortical Abnormalities in Schizophrenia Identified by Structural Magnetic Resonance Imaging.” Arch Gen Psychiatry 56 (1999): 537-547. Reprinted with the permission of

DOI link for Acknowledgments Bromet, E.J., and Fennig, S. “Epidemiology and Natural History of Schizophrenia.” Biol Psychiatry 46 (1999): 871-881. Reprinted with the permission of Elsevier Science. Heaton, R.K., Gladsjo, J. A., Palmer, B.W., Kuck, J., Marcotte, T.D., and Jeste, D.V. “Stability and Course of Neuropsychological Deficits in Schizophrenia.” Arch Gen Psychiatry 58 (2001): 24-32. Reprinted with the permission of American Medical Association. Robinson, D., Woerner, M.G., Alvir, J.M., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., and Lieberman, J. A. “Predictors of Relapse following Response from a First Episode of Schizophrenia or Schizoaffective Disorder.” Arch Gen Psychiatry 56 (1999): 241-247. Reprinted with the permission of American Medical Association. Akil, M., Pierri, J.N., Whitehead, R.E., Edgar, C.L., Mohila, C., Sampson, A.R., and Lewis, D. A. “Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects.” AmJ Psychiatry 156 (1999): 1580-1589. Copyright 1999, the American Psychiatric Association. Reprinted by permission. Arnold, S.E., Trojanowski, J.Q., Gur, R.E., Blackwell, P., Han, L.Y., and Choi, C. “Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients with Schizophrenia.” Arch Gen Psychiatry 55 (1998): 225-232. Reprinted with the permission of American Medical Association. Barch, D.M., Carter, C.S., Braver, T.S., et al. “Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients with Schizophrenia.*'Arch Gen Psychiatry 58 (2001): 280-288. Reprinted with the permission of American Medical Association. Gilbert, A.R., Rosenberg, D.R., Harenski, K., Spencer, S., Sweeney, J.A., and Keshavan, M.S. “Thalamic Volumes in Patients with First-Episode Schizophrenia.” AmJ Psychiatry 158 (2001): 618-624. Copyright 2001, the American Psychiatric Association. Reprinted by permission. Glantz, L.A., and Lewis, D.A. “Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia.” Arch Gen Psychiatry 57 (2000): 65-73. Reprinted with the permission of American Medical Association. Goff, D.C., and Coyle, J.T. “The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia.” AmJ Psychiatry 158 (2001): 1367-1377. Copyright 2001, the American Psychiatric Association. Reprinted by permission. Goldstein, J.M., Goodman, J.M., Seidman, L.J., et al. “Cortical Abnormalities in Schizophrenia Identified by Structural Magnetic Resonance Imaging.” Arch Gen Psychiatry 56 (1999): 537-547. Reprinted with the permission of

Acknowledgments Bromet, E.J., and Fennig, S. “Epidemiology and Natural History of Schizophrenia.” Biol Psychiatry 46 (1999): 871-881. Reprinted with the permission of Elsevier Science. Heaton, R.K., Gladsjo, J. A., Palmer, B.W., Kuck, J., Marcotte, T.D., and Jeste, D.V. “Stability and Course of Neuropsychological Deficits in Schizophrenia.” Arch Gen Psychiatry 58 (2001): 24-32. Reprinted with the permission of American Medical Association. Robinson, D., Woerner, M.G., Alvir, J.M., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., and Lieberman, J. A. “Predictors of Relapse following Response from a First Episode of Schizophrenia or Schizoaffective Disorder.” Arch Gen Psychiatry 56 (1999): 241-247. Reprinted with the permission of American Medical Association. Akil, M., Pierri, J.N., Whitehead, R.E., Edgar, C.L., Mohila, C., Sampson, A.R., and Lewis, D. A. “Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects.” AmJ Psychiatry 156 (1999): 1580-1589. Copyright 1999, the American Psychiatric Association. Reprinted by permission. Arnold, S.E., Trojanowski, J.Q., Gur, R.E., Blackwell, P., Han, L.Y., and Choi, C. “Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients with Schizophrenia.” Arch Gen Psychiatry 55 (1998): 225-232. Reprinted with the permission of American Medical Association. Barch, D.M., Carter, C.S., Braver, T.S., et al. “Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients with Schizophrenia.*'Arch Gen Psychiatry 58 (2001): 280-288. Reprinted with the permission of American Medical Association. Gilbert, A.R., Rosenberg, D.R., Harenski, K., Spencer, S., Sweeney, J.A., and Keshavan, M.S. “Thalamic Volumes in Patients with First-Episode Schizophrenia.” AmJ Psychiatry 158 (2001): 618-624. Copyright 2001, the American Psychiatric Association. Reprinted by permission. Glantz, L.A., and Lewis, D.A. “Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia.” Arch Gen Psychiatry 57 (2000): 65-73. Reprinted with the permission of American Medical Association. Goff, D.C., and Coyle, J.T. “The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia.” AmJ Psychiatry 158 (2001): 1367-1377. Copyright 2001, the American Psychiatric Association. Reprinted by permission. Goldstein, J.M., Goodman, J.M., Seidman, L.J., et al. “Cortical Abnormalities in Schizophrenia Identified by Structural Magnetic Resonance Imaging.” Arch Gen Psychiatry 56 (1999): 537-547. Reprinted with the permission of