ABSTRACT
Karyotyping is not often performed in transgender medicine. It is expensive, and, most of the time, a transgendered person’s birth sex phenotype and chromosomes are concordant. However, in some circumstances, transgender medicine may involve understanding the karyotype and communicating about it to the client. Clients may request a chromosome test in the course of their exploration. Clients known to have a variant karyotype may have an atypical gender identity. They may feel blended, or they may wish to consider transition. Discovery of a variant karyotype may change transitioning persons’ self-perception and cause them to identify as intersex. Also, some intersex individuals wish to reassign their gender. For example, a person with partial androgen insensitivity syndrome (PAIS) assigned to female at birth may wish to follow a path similar to that of female-to-male trangendered individuals.
