ABSTRACT
The inability to inhibit unwanted behaviors and impulses produces functional debility in a broad range of neuropsychiatric disorders. A potentially important model of impulse control is volitional tic suppression in Tourette syndrome. The most frequent cause of functional debility associated with many neuropsychiatric disorders is the inability to inhibit unwanted impulses and behaviors. Compulsions, stereotypies, impulsivity, hyperactivity, and aggression are broad classes of behavioral problems that have been variously attributed to the failed inhibition of normal brain processes. The omnibus test of statistical significance demonstrated significant increases and decreases in the global functional MRI signal change. Functional MRI signal changes reflect changes in blood flow and oxygen concentration that are an indirect measure of neuronal activity.
