This chapter deals with the nature of work and the human need for it and the psychodynamics of addictions in general. It discusses the roots, manifestations, consequences, and possible remedies of addiction to work. The manifest picture of work addiction bears many similarities to those of substance abuse and alcoholism. “Work addiction” has many causes though one or the other may predominate in a given case. Work addiction can be derived from reaction formation against unruly instincts, substitution of relationships by work, defense against indolence, and search for immortality. Work addiction is often accompanied by vulnerability to other addictions. Treating work addiction may be a moot point since most individuals afflicted with it do not seek help. Their condition is largely ego-syntonic and even pleasurable. Their consumption with work provides them with social approval and monetary rewards. Work addiction appears more of a self-sacrificing virtue than a sadistic ailment.