Design for sustainability is, ultimately, design for human and planetary health. A regenerative human culture is healthy, resilient and adaptable; it cares for the planet and it cares for life in the awareness that this is the most effective way to create a thriving future for all of humanity. Sustainability is first and foremost about systemic health and resilience at different scales, from local, to regional and global. One proposal for guiding wise action in the face of dynamic complexity and ‘not knowing’ is to apply the Precautionary Principle as a framework that aims to avoid, as far as possible, actions that will negatively impact on environmental and human health in the future. A new cultural narrative is emerging, capable of birthing and informing a truly regenerative human culture. A regenerative culture will emerge out of finding and living new ways of relating to self, community and to life as a whole.