The aim of the present contribution is to defend a specific version of moderate skeptical invariantism, which I call Practical Skeptical Invariantism (PSI). The view is a form of skepticism to the extent that it denies knowledge of many facts that we ordinarily think or claim to know. It is moderate to the extent that it is supposed to be compatible with a quite weak, non-radical form of skepticism. According to this view, the threshold on evidential support required for knowledge should be partially fixed by the practical circumstances of the subject: someone is in a position to know a proposition p only if she would be rational to act as if p even if the practical stakes on p were maximally high. I consider and address what I take to be the most pressing problem for the view, namely, that the view can’t avoid a collapse into a radical form of skepticism. Moreover, I propose a positive argument for this view. The argument relies on the claim that judgments in high stakes are generally more reliable than in low stakes.